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 Formulary Chapter 4: Central nervous system - Full Chapter
04.01  Expand sub section  Hypnotics and anxiolytics
04.01.01  Expand sub section  Hypnotics
 note 

NICE CG113: Generalised anxiety disorder and panic disorder in adults:management

Controlled Drug Temazepam Tablets
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Second Choice
Green
Temazepam Tablet 10mg
Temazepam Tablet 20mg

CSM Advice: Hypnotics and Anxiolytics are indicated for the short-term relief of sleep disturbance and/or anxiety. (For continuous use up to a maximum of 14 days).

This is second choice due to its higher cost acquisition compared to Z Drugs 
   
Melatonin  (Circadin ®)
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Formulary
Amber E

See link below for ESCA's. 

Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

When a patient cannot swallow, Circadin MR tablets can be crushed (note – this would change it from a modified-release tablet to an immediate-release one) and mixed or dissolved in 15-30mL of water for administration via enteral feeding tubes or easier swallowing.

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
04.01.01  Expand sub section  Benzodiazepines
04.01.01  Expand sub section  Zaleplon, Zolpidem and Zopiclone
Zopiclone
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First Choice
Green

Zopiclone Tablet 3.75mg
Zopiclone Tablet 7.5mg


CSM Advice: Hypnotics and Anxiolytics are indicated for the short-term relief of sleep disturbance and/or anxiety. (For continuous use up to a maximum of 14 days).

Zaleplon, zolpidem and zopiclone for the short-term management of insomnia (April 2004)
Zaleplon, zolpidem and zopiclone are recommended for the short-term management of severe insomnia that interferes with normal daily life, and should be prescribed for short periods of time only. www.nice.org.uk/TA77

NB: Zaleplon is discontinued and Zolpidem is non-formulary

 
04.01.02  Expand sub section  Anxiolytics to top
04.01.02  Expand sub section  Benzodiazepines
Diazepam Tablets
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Formulary
Green
Diazepam Tablet 2mg
Diazepam Tablet 5mg
Diazepam Tablet 10mg
Diazepam 2mg/5ml Oral Solution SF

Diazepam 10mg/5ml Oral Solution SF SPECIAL ITEM Expensive


CSM Advice: Hypnotics and Anxiolytics are indicated for the short-term relief of sleep disturbance and/or anxiety. (For continuous use up to a maximum of 14 days).
 
   
Lorazepam
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Formulary
Green
Lorazepam Tablet 1mg
Lorazepam Tablet 2.5mg
Lorazepam Tablet 500mcg

CSM Advice: Hypnotics and Anxiolytics are indicated for the short-term relief of sleep disturbance and/or anxiety. (For continuous use up to a maximum of 14 days).
 
   
Chlordiazepoxide
(Also see Section 4.10)
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Formulary
Green
Chlordiazepoxide HCl Capsule 5mg
Chlordiazepoxide HCl Capsule 10mg

CSM Advice: Hypnotics and Anxiolytics are indicated for the short-term relief of sleep disturbance and/or anxiety. (For continuous use up to a maximum of 14 days).



 
   
04.01.03  Expand sub section  Barbiturates
04.02  Expand sub section  Drugs used in psychoses and related disorders
04.02.01  Expand sub section  Antipsychotic Drugs
Chlorpromazine
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Formulary
Green
Chlorpromazine HCl Oral Solution 100mg/5ml
Chlorpromazine HCl Oral Solution 25mg/5ml
Chlorpromazine HCl Tablet 25mg
Chlorpromazine HCl Tablet 50mg
Chlorpromazine HCl Tablet 100mg 
   
Haloperidol
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Formulary
Green
Haloperidol 500microgram Tablets
Haloperidol 1.5mg Tablets
Haloperidol 5mg Tablets
Haloperidol 10mg Tablets
Haloperidol 1mg/5ml Oral Solution (Halkid)
Haloperidol 5mg/5ml Oral Solution SF 
Haloperidol 10mg/5ml Oral Solution SF
 
   
Sulpiride
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Formulary
Green
Sulpiride Tablets 200mg
Sulpiride Tablets 400mg  
   
04.02.01  Expand sub section  Second-Generation Antipsychotic Drugs to top
Amisulpride
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Formulary
Amber E

Amisulpride Tablet 50mg
Amisulpride Tablet 100mg
Amisulpride Tablet 200mg
Amisulpride Tablet 400mg
Amisulpride Oral Solution 100mg/ml SF

See link below for ESCA's.  Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA) - MPFT
   
Aripiprazole
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Formulary
Amber E
High Cost Medicine

FIRST CHOICE
Aripiprazole Tablet 5mg
Aripiprazole Tablet 10mg
Aripiprazole Tablet 15mg
Aripiprazole Tablet 30mg

SECOND CHOICE
Aripiprazole Orodispersible Tablet 10mg S/F
Aripiprazole Orodispersible Tablet 15mg S/F

THIRD CHOICE
Aripiprazole Oral Solution 5mg/5ml- Use liquid only in patients with swallowing difficulties

prescribe generically

See link below for ESCA's.  Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
Link  NICE TA213: Aripiprazole for the treatment of schizophrenia in people aged 15 -17 years
Link  NICE TA292: Bipolar disorder (children) - aripiprazole
   
Clozapine (Clozaril®)
(Prescribe by brand)
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Restricted Drug Restricted
Red

Clozapine Tablet 25mg
Clozapine Tablet 50mg
Clozapine Tablet 100mg 
Clozapine Tablet 200mg

Clozapine for treatment resistant schizophrenia in patients who have failed to respond to 2 Antipsychotics - NICE CG178

Restriction: Initiation by psychiatrist registered with Clozapine monitoring service

Patient, prescriber and supplying pharmacist must be registered with the Patient Monitoring Service. Treatment is only continued if there are acceptable leucocyte and neutrophil counts.

Brands include Clozaril, Denzapine or Zaponex

MHRA/CHM advice: Clozapine: reminder of potentially fatal risk of intestinal obstruction, faecal impaction, and paralytic ileus (October 2017)

 
   
Olanzapine (Zyprexa®)
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Formulary
Amber E

Olanzapine Tablet 2.5mg
Olanzapine Tablet 5mg
Olanzapine Tablet 7.5mg
Olanzapine Tablet 10mg
Olanzapine Tablet 15mg
Olanzapine Tablet 20mg
Olanzapine Orodisper Tablet 5mg
Olanzapine Orodisper Tablet 10mg
Olanzapine Orodisper Tablet 15mg

Do not prescribe Oral Lyophilisates preparations Very Expensive-Applicable in Primary care only.

See link below for ESCA's.  Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Quetiapine
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Formulary
Amber E

FIRST CHOICE- normal release tablets
Quetiapine Tablet 25mg
Quetiapine Tablet 100mg
Quetiapine Tablet 150mg
Quetiapine Tablet 200mg
Quetiapine Tablet 300mg

SECOND CHOICE - MR where there are compliance issues
Zaluron XL Tablet 50mg
Zaluron XL tablet 150mg
Zaluron XL Tablet 200mg
zaluron XL Tablet 300mg
zaluron XL Tablet 400mg

THIRD CHOICE
Biquelle XL Tablet 50mg
Biquelle XL tablet 150mg
Biquelle XL Tablet 200mg
Biquelle XL Tablet 300mg
Biquelle XL Tablet 400mg

See link below for ESCA's.  Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 

Prescribers should choose the most cost-effective option (Applicable in Primary care only)

 

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Risperidone
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Formulary
Amber E

Risperidone Tablet 500mcg
Risperidone Tablet 1mg
Risperidone Tablet 2mg
Risperidone Tablet 3mg
Risperidone Tablet 4mg
Risperidone Orodisper Tablet 500mcg SF
Risperidone Orodisper Tablet 1mg SF
Risperidone Orodisper Tablet 2mg SF
Risperidone Orodisper Tablet 3mg SF
Risperidone Orodisper Tablet 4mg SF
Risperidone Oral Solution 1mg/ml SF

See link below for ESCA's.  Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
04.02.02  Expand sub section  Antipsychotic depot injections
Aripiprazole  (Abilify Maintena®)
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Formulary
Red

Aripiprazole 400mg powder and solvent for sust-release susp for inj in vial or pre-filled syringe

 
   
Flupentixol Decanoate
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Restricted Drug Restricted
Red
Flupentixol Decanoate Injection 20mg/ml 1ml Amp
Flupentixol Decanoate Injection 20mg/ml 2ml Amp
Flupentixol Decanoate Injection 100mg/ml 0.5ml Amp
Flupentixol Decanoate Injection 100mg/ml 1ml Amp
Flupentixol Decanoate Injection 200mg/ml 1ml Amp
 
   
Fluphenazine Decanoate
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Restricted Drug Restricted
Red

Fluphenazine Decanoate Injection 20mg/ml 5ml Amp
Fluphenazine Decanoate Injection 25mg/ml 0.5ml Amp
Fluphenazine Decanoate Injection 25mg/ml 1ml Amp
Fluphenazine Decanoate Injection 25mg/ml 2ml Amp
Fluphenazine Decanoate Injection 100mg/ml 0.5ml Amp
Fluphenazine Decanoate Injection 100mg/ml 1ml Amp

 
   
Haloperidol (Haldol Decanoate®)
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Restricted Drug Restricted
Red
Haloperidol Decanoate Injection 50mg/ml 1ml Amp
Haloperidol Decanoate Injection 100mg/ml 1ml Amp
 
   
Paliperidone (Xeplion®)
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Restricted Drug Restricted
Red

Paliperidone 50mg/0.5ml suspension for injection pre-filled syringes 
Paliperidone 75mg/0.75ml suspension for injection pre-filled syringes 
Paliperidone 100mg/1ml suspension for injection pre-filled syringes 
Paliperidone 150mg/1.5ml suspension for injection pre-filled syringes

 
   
Risperidone (Risperdal Consta®)
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Restricted Drug Restricted
Red
Risperidone Powder for reconstitution 25mg vial
Risperidone Powder for reconstitution 37.5mg vial
Risperidone Powder for reconstitution 50mg vial 
   
Zuclopenthixol Decanoate
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Restricted Drug Restricted
Red
Zuclopenthixol Decanoate Injection 200mg/ml 1ml Amp
Zuclopenthixol Decanoate Injection 500mg/ml 1ml Amp
 
   
04.02.03  Expand sub section  Drugs used for mania and hypomania
04.02.03  Expand sub section  Valproic acid
Valproic Acid (Semisodium)
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Formulary
Amber

Valproic Acid Tablet EC 250mg (As Semisodium Valproate)
Valproic Acid Tablet EC 500mg (As Semisodium Valproate)

Please see the following links to materials to support the new Valproate Pregnancy Prevention Programme:

Patient Card – to be given by pharmacists to all female patients who are dispensed valproate medicines to inform them of the risks
Patient Guide – to be provided to girls (of any age) and women of childbearing potential (or their parent/caregiver/responsible person) taking any medicine containing valproate
Guide for healthcare professionals – for all prescribers, pharmacists, and other healthcare providers involved in the care of women and girls of childbearing potential using valproate medicines
Risk Acknowledgement Form – for the specialist and patient (or their parent/caregiver/responsible person) to sign at initiation and at treatment reviews at least every year. The patient should receive a copy of the form; one copy should be filed in the specialist notes, and one copy sent to the patient’s GP

 
   
04.02.03  Expand sub section  Lithium
Lithium Carbonate
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Formulary
Amber E

Prescribe by Brand and maintain patient on the same Brand

Current Brands Available:
Camcolit, Lithonate, Liskonum and Priadel Tablets


Note change in bioavailability when changing from Tablets to Liquid. Lithium citrate tetrahydrate 520 mg (liquid) is equivalent to lithium carbonate 204 mg (tablet)

Preparations vary widely in bioavailability; changing the preparation requires the same precautions as initiation of treatment (Litium Carbonate)

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Lithium Citrate
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Formulary
Amber E

Prescribe by Brand and maintain patient on the same Brand

Current Brands Available:
Priadel Liquid and Li-liquid

Note change in bioavailability when changing from Tablets to Liquid. Note Lithium citrate tetrahydrate 520 mg is equivalent to lithium carbonate 204 mg.
Preparations vary widely in bioavailability; changing the preparation requires the same precautions as initiation of treatment (Lithium Carbonate)

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
Link  Safer Lithium Therapy
   
04.03  Expand sub section  Antidepressant drugs to top
04.03.01  Expand sub section  Tricyclic and related antidepressant drugs
04.03.01  Expand sub section  Tricyclic antidepressants
Lofepramine
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Formulary
Green
Lofepramine HCl Tablet 70mg 
   
Amitriptyline
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Formulary
Green
Amitriptyline HCl Tablet 10mg
Amitriptyline HCl Tablet 25mg
Amitriptyline HCl Tablet 50mg
Amitriptyline HCl Oral Solution 25mg/5ml S/F
Amitriptyline HCl Oral Solution 50mg/5ml S/F
 
   
Clomipramine
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Formulary
Green
Clomipramine HCl Capsule 10mg
Clomipramine HCl Capsule 25mg
Clomipramine HCl Capsule 50mg
 
   
Dosulepin
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Formulary
Amber

Dosulepin HCl Capsule 25mg
Dosulepin HCl Tablet 75mg

NOT for new patients - more toxic in overdose. (MHRA December 2007).

NHS England has identified this product as an item that should not be routinely prescribed in primary care. Where ongoing primary care prescribing is agreed in exceptional circumstances, there should be a co-operative relationship within a multidisciplinary team (July 2017).

 
Link  Dosulepin 75 mg Tablets
   
04.03.02  Expand sub section  Monoamine-oxidase inhibitors
04.03.03  Expand sub section  Selective serotonin re-uptake inhibitors
Sertraline
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First Choice
Green
Sertraline HCl Tablet 50mg
Sertraline HCl Tablet 100mg
 
Citalopram
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First Choice
Green
Citalopram Hydrobromide Tablet 10mg
Citalopram Hydrobromide Tablet 20mg
Citalopram Hydrobromide Tablet 40mg
Citalopram HCl Oral Drops 40mg/ml S/F

Cost effective choice in patients where QT interval prolongation is not an issue (see MHRA advice below for detail) Maximum daily dose 40 mg for adults; 20 mg for patients older than 65 years; and 20 mg for those with hepatic impairment. 
Escitalopram (Cipralex®)
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Formulary
Green

Escitalopram Tablet 5mg
Escitalopram Tablet 10mg
Escitalopram Tablet 20mg
Escitalopram Oral Drops 10mg/ml S/F


See MHRA advice on QT prolongation. Maximum daily dose 20 mg for adults; 10 mg for patients older than 65 years; and 10 mg for those with hepatic impairment.

 
Link  Citalopram and escitalopram: QT interval prolongation
   
Fluoxetine
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Formulary
Amber E

Treatment in Adolescents

Fluoxetine HCl Capsule 20mg
Fluoxetine Liquid 20mg/5ml (Prescribe Liquid for doses less than 20mg)

See link below for ESCA's. 

Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Aggreements - SSSFT
   
Fluoxetine
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Formulary
Green
Treatment in Adults

Fluoxetine HCl Capsule 20mg
Fluoxetine 20mg orodispersible tablets

Use the orodispersible tablets where there are swallowing difficulties or patient is on a 10mg dose as the tablet can be divided into equal halves to get the correct dose. This is much more cost effective then the oral solution 
   
Paroxetine
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Formulary
Amber
Paroxetine HCl Tablet 20mg
Paroxetine HCl Tablet 30mg
Paroxetine Oral Suspension 10mg/5ml SF

Withdrawal syndrome is more common with paroxetine - Royal College of Psychiatrists 
Link  Coming off antidepressants
   
Vortioxetine (Brintellix)
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Formulary
Amber

5mg Tablets
10mg Tablets
20mg Tablets

 

Vortioxetine is recommended as an option for treating major depressive

episodes in adults whose condition has responded inadequately to

2 antidepressants within the current episode.

 

 
Link  TA367 - Vortioxetine for treating major depressive episodes
   
04.03.04  Expand sub section  Other antidepressant drugs to top
Venlafaxine Tablets
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Formulary
Green
Venlafaxine Capsules 75mg
 
   
Venlafaxine M/R capsules
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Formulary
Green
Venlafaxine Capsules 75mg M/R
Venlafaxine Capsules 150mg M/R
Venlafaxine Capsules 225mg M/R (prescribe 225mg strength as Vensir)

Drug tariff price for 75mg and 150mg capsules now based on Vensir so can be prescribed generically

Please note licensed in depression and not anxiety
 
   
Venlafaxine M/R Tablets
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Formulary
Green
Venlafaxine tablets 75mg M/R
Venlafaxine tablets 150mg M/R
Venlafaxine tablets 225mg M/R

Prescribe generically.

Please note first line is Vensir mr caspules for depression
However the tablets are licensed in anxiety.
 
   
Mirtazapine
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Formulary
Green
Mirtazapine Tablet 15mg
Mirtazapine Tablet 30mg
Mirtazapine Tablet 45mg

Mirtazapine Orodisper Tab 15mg
Mirtazapine Orodisper Tab 30mg
Mirtazapine Orodisper Tab 45mg

 
   
Duloxetine (Cymbalta®)
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Formulary
Amber
Duloxetine HCl Capsule G/R 30mg
Duloxetine HCl Capsule G/R 60mg
 
   
04.04  Expand sub section  CNS stimulants and other drugs used for attention deficit hyperactivity disorder
Controlled Drug Methylphenidate hydrochoride
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First Choice
Amber E

Restriction: Initiation and stabilisation by specialist
 
Note Different versions of modified-release preparations may not have the same clinical effect. To avoid confusion between these different formulations of methylphenidate, prescribers should specify the brand to be dispensed

See link below for ESCA.  Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 

 
Atomoxetine (Strattera®)
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Formulary
Amber E

Atomoxetine HCl Capsule 10mg
Atomoxetine HCl Capsule 18mg
Atomoxetine HCl Capsule 25mg
Atomoxetine HCl Capsule 40mg
Atomoxetine HCl Capsule 60mg
Atomoxetine HCl Capsule 80mg
Atomoxetine HCl Capsule 100mg

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreement (ESCA’s) -MPFT
   
Controlled Drug Dexamfetamine
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Formulary
Amber E

Dexamfet Sulfate Tablet 5mg

See link below for ESCA's. Please use the ESCA's under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Lisdexamfetamine (Elvanse®)
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Formulary
Amber E

Lisdexamfetamine 20mg cap 
Lisdexamfetamine 30mg cap
Lisdexamfetamine 40mg cap
Lisdexamfetamine 50mg cap
Lisdexamfetamine 60mg cap
Lisdexamfetamine 70mg cap

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
04.05  Expand sub section  Drugs used in the treatment of obesity
Liraglutide (Saxenda®)
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Formulary
Red
CCG

Restriction: In line with NICE Guidance

 

The CCG does not currently have a Tier 3 commissioned service to manage overweight and obesity

 
Link  NICE TA664: Liraglutide for managing overweight and obesity
   
04.05.01  Expand sub section  Anti-obesity drugs acting on the gastro-intestingal tract
Orlistat
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Formulary
Green
Orlistat Capsule 120mg

Initiated ONLY after trial of weight loss. Should not prescribe outside its limited licensed indication. Treatment with orlistat should be discontinued after 12 weeks if less than 5% of the body weight has been lost since the start of therapy.

 
   
04.05.02  Expand sub section  Centrally acting appetite suppressants
04.06  Expand sub section  Drugs used in nausea and vertigo to top
04.06  Expand sub section  Antihistamines
Cinnarizine
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Formulary
Green
Cinnarizine Tablet 15mg 
   
Cyclizine
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Formulary
Green
Cyclizine HCl Tablet 50mg 
   
04.06  Expand sub section  Phenothiazines and related drugs
Prochlorperazine
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Formulary
Green


 

 
   
Droperidol
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Formulary
Red

Restriction: For initiation by specialists in anaesthetics only

Rescue therapy (3rd line antiemetic) for post-operative nausea and vomiting (PONV) in children and adolescents aged 2 – 18 years old who do not respond adequately to dexamethasone or ondansetron (as monotherapy or in combination)

 
   
04.06  Expand sub section  Domperidone and metoclopramide
Domperidone
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Formulary
Green

Domperidone Tablet 10mg

The MHRA has advised that there is a small risk of serious ventricular arrhythmia and sudden cardiac death with domperidone. See link below

MHRA advice: Domperidone- risk of cardiac side-effects (Dec 2014)

MHRA (Dec 2019): Domperidone is no longer licensed for use in children younger than 12 or those weighing less than 35 kg. 

 
Link  MHRA Alert on Domperidone (Dec 2019)
Link  MHRA May 2014 - Domperidone: risks of cardiac side effects
   
Metoclopramide
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Formulary
Green
Metoclopramide HCl Tablet 10mg

Avoid SR form as very expensive. Do not use in people <20 years. MHRA recommend use for no more than 5 days.

 
Link  EMEA for Metoclopramide
Link  MHRA Aug 2013 - Metoclopramide: risk of neurological adverse effects
Link  MHRA Guidance - Metroclopramide
   
04.06  Expand sub section  5HT3 antagonists
Granisetron
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Restricted Drug Restricted
Red
 
   
Ondansetron
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Formulary

Amber Amber for licensed indications of post operative nausea and vomiting ,and nausea and vomiting related to chemotherapy.

AmberAmber for the unlicensed indications of pallitative care where recommended by the pallitative care team.

Red Traffic Light  For all other indications

Tablets are the preferred formulation.

If patient has swallowing difficulties the most cost effective option for both 4mg and 8mg strength are the Setofilm® orodisperible films as the liquid and generically prescribed orodispersible tablets and melts are more expensive. These must be prescribed by brand Setofilm.

Please note these are still considerably more expensive then the normal release tablets.

MHRA advice: Ondansetron- small increased risk of oral clefts following use in the first 12 weeks of pregnancy (Jan 2020)

 
   
04.06  Expand sub section  Neurokinin receptor antagonist to top
Aprepitant (Emend®)
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Restricted Drug Restricted
Red
 
   
04.06  Expand sub section  Other drugs for Ménière's disease
Betahistine Dihydrochloride
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Formulary
Green

Betahistine HCl Tablet 8mg
Betahistine HCl Tablet 16mg

ONLY Licensed for Meniere's Disease.

 
   
04.07  Expand sub section  Analgesics
Paracetamol
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Formulary
Green
Paracetamol Tablet 500mg
Paracetamol Capsule 500mg - More Expensive than Tablets
Paracetamol Tablet Soluble 500mg - More Expensive than Tablets

Paracetamol Oral Solution Paediatric 120mg/5ml
Paracetamol Oral Solution Paediatric 120mg/5ml S/F
Paracetamol Oral Suspension 250mg/5ml
Paracetamol Oral Suspension 250mg/5ml S/F
Paracetamol Syrup 120mg/5ml


 
Link  UKMI Q&A: Can Breastfeeding mothers take paracetamol?
   
Ibuprofen
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Formulary
Green
Tablets 200 and 400mg
Oral Suspension SF 100mg/5ml
Oral Suspension 100mg/5ml



See also section 10.1.1
 
Link  Click Here to go to Section 10.1.1:
   
04.07.01  Expand sub section  Non-opioid analgesics and compound analgesic preparations
04.07.01  Expand sub section  Compound analgesic preparations
Co-Codamol - 8/500mg
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Formulary
Green

Co-Codamol Tablet 8mg/500mg
Co-Codamol Effervescent Tablet 8mg/500mg

NOT an evidence based choice but patients may perceive benefit.
Please note over the counter (OTC) sale is limited to three days only.

 
   
Co-Codamol - 30/500mg
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Formulary
Green

Co-Codamol Capsule 30mg/500mg
Co-Codamol Tablet 30mg/500mg
Co-Codamol Effervescent Tablet 30mg/500mg

Prescribing as separate components allows dosing flexibility and is less expensive (Applicable to primary care only).

Ensure soluble forms are prescribed only if appropriate.

 
   
04.07.02  Expand sub section  Opioid analgesics to top
 note 

The Faculty of Pain Medicine has produced resources for healthcare professionals around opioid prescribing:www.fpm.ac.uk/faculty-of-pain-medicine/opioids-aware

MHRA safety leaflet: Opioid medicines and the risk of addiction

Codeine Phosphate
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Formulary
Green
Codeine Phos Tablet 15mg
Codeine Phos Tablet 30mg
Codeine Phos Tablet 60mg
Codeine Phos Linctus 15mg/5ml S/F
 
   
Controlled Drug Dihydrocodeine Tartrate
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Formulary
Green
Dihydrocodeine Tartrate Tablet 30mg 
   
Controlled Drug Tramadol
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Formulary
Green
Tramadol HCl Capsule 50mg

Tramulief SR 100 mg tablets
Tramulief SR 150 mg tablets
Tramulief SR 200 mg tablets

ONLY use M/R Preparation if compliance really is a problem 
Link  Tramadol and seizures - MHRA CSM Guidance 1996
Link  UKMI Q&A: risk of developing Serotonin Syndrome following concomitant use of tramadol with selective serotonin reuptake inhibitors (SSRIs)
   
Controlled Drug Morphine Sulfate - Oral Solution
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Formulary
Green
Morph Sulfate Oral Solution 10mg/5ml (POM)
Morph Sulfate Oral Solution 20mg/1ml (Controlled Drug)
 
   
Controlled Drug Morphine Sulfate (ZOMORPH CAPSULES)
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Formulary
Green

Zomorph Capsule 10mg M/R
Zomorph Capsule 30mg M/R 
Zomorph Capsule 60mg M/R  
Zomorph Capsule 100mg M/R 
Zomorph Capsule 200mg M/R 
 
 
Prescribe M/R Capsules as brand Zomorph in preference to M/R Tablets as more cost effective. Please prescribe by brand to avoid medication errors (Applicable in Primary care only).

 
   
Controlled Drug Oxycodone
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Formulary
Green

Shortec Capsule 5mg 
Shortec Capsule 10mg 
Shortec Capsule 20mg

Longtec HCl Tablet 5mg M/R
Longtec HCl Tablet 10mg M/R 
Longtec HCl Tablet 15mg M/R
Longtec HCl Tablet 20mg M/R 
Longtec HCl Tablet 30mg M/R
Longtec HCl Tablet 40mg M/R 
Longtec HCl Tablet 60mg M/R
Longtec HCl Tablet 80mg M/R

Longtec HCl Tablet 120mg M/R

Oxycodone HCl Oral Solution 10mg/1ml S/F
Oxycodone HCl Oral Solution 5mg/5ml S/F

 

Please prescribe the normal release as Shortec® and the modified release as longtec® as this is more cost effective (Applicable in Primary care only).

 
   
Controlled Drug Fentanyl
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Formulary
Green

Fencino Transdermal Patch 12mcg/hr
Fencino Transdermal Patch 25mcg/hr
Fencino Transdermal Patch 50mcg/hr
Fencino Transdermal Patch 75mcg/hr
Fencino Transdermal Patch 100mcg/hr

Useful if patient cannot swallow tablets
Prescribe by Brand - Fencino recommended 
(Applicable in Primary care only). 

 
   
Controlled Drug Buprenorphine 5mcg Patch (BuTec® patch)
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Restricted Drug Restricted
Green

Please prescribe by brand Butec® (equivalent to Butrans®) as more cost effective (Applicable in Primary care only).

Note: Low dose may be useful for frail elderly patients or similar patients sensitive to side-effects of morphine sulphate or fentanyl

Self-adhesive, beige, buprenorphine, ‘5’ patch (releasing 5 micrograms/hour for 7 days)

See the Strong Opioids for Persistant Non-Cancer Pain Guidelines for further information

 
Link  Strong Opioids for Persistant Non-Cancer Pain Guidelines
   
Controlled Drug Buprenorphine 35mcg Patch (Transtec® patch)
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Restricted Drug Restricted
Green

Note: Low dose may be useful for frail elderly patients or similar patients sensitive to side-effects of morphine sulphate or fentanyl

Self-adhesive, skin-coloured, buprenorphine, ‘35’ patch (releasing 35 micrograms/hour for 96 hours)

See the Strong Opioids for Persistant Non-Cancer Pain Guidelines for further information  
Link  Strong Opioids for Persistent Non-Cancer Pain
   
Controlled Drug Diamorphine
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Formulary
Green

Diamorphine Tablets 10mg

5mg Powder for Soln for Injection Ampoules 
10mg Powder for Soln for Injection Ampoules
30mg Powder for Soln for Injection Ampoules
100mg Powder for Soln for Injection Ampoules

500mg Powder for Soln for Injection Ampoules

 
Link  22/05/2019: Diamorphine 5mg injection supply issues
   
04.07.03  Expand sub section  Neuropathic pain
Amitriptyline
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Formulary
Green
Amitriptyline Tablets 10mg, 25mg, 50mg




Unlicensed use in Neuropathic Pain is recommended by NICE CG96 
   
Controlled Drug Gabapentin
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Formulary
Green

Capsules 100mg
Capsules 300mg
Capsules 400mg

Oral Solution 50mg/ml

CDAs of the 1st April 2019 Gabapentin is re-classified as a Schedule 3 Controlled Drug

 
   
Controlled Drug Pregabalin
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Formulary
Green

Pregabalin Capsule 25mg
Pregabalin Capsule 50mg
Pregabalin Capsule 75mg
Pregabalin Capsule 100mg
Pregabalin Capsule 150mg
Pregabalin Capsule 200mg
Pregabalin Capsule 225mg
Pregabalin Capsule 300mg
Pregabalin Oral Soln 100mg/5ml S/F - for patients with swallowing difficulties ONLY

The Capsules are flat priced so dose optimise when increasing Daily Doses, e.g. 1x50mg twice a day is cheaper to prescribe than 2x25mg twice a day.

CDAs of the 1st April 2019 Pregabalin is re-classified as a Schedule 3 Controlled Drug

 
   
Carbamazepine
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Formulary
Green
Tablets 100mg
Tablets 200mg
Tablets 400mg

 
   
Nortriptyline
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Formulary
Green
Allegron Tablets 10mg and 25mg

Please note the 10mg & 25mg Tablets are VERY EXPENSIVE items 
   
04.07.04  Expand sub section  Antimigraine drugs
04.07.04.01  Expand sub section  Treatment of the acute migraine attack
Aspirin
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Formulary
Green
Aspirin Tablet 300mg

Because of an association with Reye's syndrome, preparations containing aspirin should not be offered to people aged under 16 years. 
Link  MHRA : Oral salicylate gels: not for use in those younger than age 16 years
   
Paracetamol (See Section 4.7.1)
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Formulary
Green
 
   
Domperidone
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Formulary
Green
Please refer to Section 4.6 
Link  Click Here to go to Section 04.07:
   
Metoclopramide (Section 4.6 also)
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Formulary
Green
Please refer to section 4.6

Metoclopramide HCl Tablet 10mg 
Link  Click Here to go to Section 04.07:
   
04.07.04.01  Expand sub section  5HT1 agonists
Sumatriptan
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Formulary
Green
Sumatriptan Tablet 100mg
Sumatriptan Tablet 50mg
Sumatriptan Aq Nasal Spray 20mg/0.1ml Ud
 
   
Zolmitriptan
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Formulary
Green

NICE Recommend this for Menstrual-related Migraine. If this is not tolerated then consider Frovatriptan 2.5mg tablets instead for menstrual related migraine. (Unlicensed indication)

 
   
Rizatriptan
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Formulary
Green
 
   
04.07.04.02  Expand sub section  Prophylaxis of migraine to top
Botulinum Toxin Type A (Botox®)
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Formulary
Red
High Cost Medicine
CCG
BlueTeq

Restriction: In line with NICE Guidance only

 
Link  NICE TA260: Botulinum toxin type A for the prevention of headaches in adults with chronic migraine
   
ErenumabBlack Triangle (Aimovig®)
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Formulary
Red
High Cost Medicine
CCG
BlueTeq

Restriction: In line with NICE Guidance only

 
Link  NICE TA682: Erenumab for preventing migraine
   
FremanezumabBlack Triangle (Ajovy®)
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Formulary
Red
High Cost Medicine
CCG
BlueTeq

Restriction: In line with NICE Guidance only

 
Link  NICE TA631: Fremanezumab for preventing migraine
   
GalcanezumabBlack Triangle (Emgality®)
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Formulary
Red
High Cost Medicine
CCG
BlueTeq

Restriction: In line with NICE Guidance only

 
Link  NICE TA659: Galcanezumab for preventing migraine
   
Pizotifen
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Formulary
Green

Pizotifen Malate_Tab 1.5mg
Pizotifen Malate_Tab 500microgram

Liquid Preparations are Unlicensed and Expensive

 
   
Propranolol
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Formulary
Green
See Section 2.4

See link for Chapter 2.4.9 
Link  Beta-Adrenoceptor blocking Drugs - Propanolol Hydrochloride
   
Topiramate Tablets
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Formulary
Green
Topiramate Tabs 25mg
Topiramate Tabs 50mg
Topiramate Tabs 100mg
Topiramate Tabs 200mg

 
Link  Control of the Epilepsies - Topiramate
   
04.07.04.03  Expand sub section  Cluster headache
04.08  Expand sub section  Antiepileptics
04.08.01  Expand sub section  Control of epilepsy
 note 

Category

Antiepileptic drugs

MHRA Advice

1

phenytoin, carbamazepine, phenobarbital, primidone

For these drugs, doctors are advised to ensure that their patient is maintained on a specific manufacturer’s product

2

valproate, lamotrigine, perampanel, retigabine, rufinamide, clobazam, clonazepam, oxcarbazepine, eslicarbazepine, zonisamide, topiramate

For these drugs, the need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history

3

levetiracetam, lacosamide, tiagabine, gabapentin, pregabalin, ethosuximide, vigabatrin  

For these drugs, it is usually unnecessary to ensure that patients are maintained on a specific manufacturer’s product unless there are specific reasons such as patient anxiety and risk of confusion or dosing errors

BRIVARACETAM (Briviact®)
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Formulary
Amber

Brivaracetam 10mg tablets
Brivaracetam 25mg tablets
Brivaracetam 50mg tablets
Brivaracetam 75mg tablets
Brivaracetam 100mg tablets
Brivaracetam 10mg/ml oral solution
Brivaracetam 50mg/5ml solution for injection vials

For adjunctive therapy in the treatment of partial onset seizures with or without secondary generalisation in adult, adolescent and paediatric patients from 4 years of age with severe refractory epilepsy warrenting epilepsy specialist input who have

  1. Tried 3 or more antiepileptic medications, and
  2. Have used Levetiracetam and has documented intolerance, and would not be suitable for other 3rd line agents; and
  3. Is currently on a 3rd line agent which would be replaced by Brivaracetam: or
  4. Has 3 or more antiepileptic medications and has insufficient symptom control and requires rapid attainment of therapeutic levels.

Restriction: For initiation and stabilisation by a specialist
Unnecessary to maintain patient on specific manufacturer's products.

After stabilisation, primary care may continue its prescribing on receipt of Specialist Clinic patient-specific letter which must include:

  • The previous antiepileptic medications tried
  • Intolerance to Levetiracetam
  • An improvement in side effects after switching from Levetiracetam to Brivaracetam
 
   
Controlled Drug Cannabidiol (Epidyolex®)
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Formulary
Red
High Cost Medicine
NHS England

Restriction: In line with NICE Guidance only

  • For treating seizures associated with Lennox-Gastaut syndrome [adjunctive treatment with clobazam] specialist use only
  • For treating seizures associated with Dravet syndrome [adjunctive treatment with clobazam] specialist use only
 
Link  NICE TA614: Cannabidiol with clobazam for treating seizures associated with Dravet syndrome
Link  NICE TA615: Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome
   
Lacosamide  (Vimpat ® )
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Formulary
Amber

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products

 
   
04.08.01  Expand sub section  Carbamazepine and Oxcarbazepine
Carbamazepine
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Formulary
Amber

Prescribe by Brand

Drug choice for simple/partial seizures and tonic clonic seizures.
Start low dose (100-200mg daily) and build up every two weeks.

Restriction: Initiation and stabilisation by specialist
Maintain patient on specific manufacturer's products.

 

 
Link  UKMI Q&A: Why is there a limit on the dose and duration of use for carbamazepine suppositories?
   
Eslicarbazepine (Zebinix®)
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Formulary
Red

Eslicarbazepine 200mg tablets
Eslicarbazepine 800mg tablets

Restriction: By specialist only
Unnecessary to maintain patient on specific manufacturer's products.

 
   
Oxcarbazepine (Trileptal®)
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Formulary
Amber

Oxcarbazepine Tablet 150mg
Oxcarbazepine Tablet 300mg
Oxcarbazepine Tablet 600mg
Oxcarbazepine Oral Suspension 300mg/5ml

Restriction: Initiation and stabilisation by specialist
Maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Ethosuximide to top
Ethosuximide
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Formulary
Green

Ethosuximide Oral Solution 250mg/5ml
Ethosuximide Capsule 250mg

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Gabapentin and pregabalin
Controlled Drug Gabapentin
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Formulary
Green

Gabapentin Capsule 100mg
Gabapentin Capsule 300mg
Gabapentin Capsule 400mg

CD As of the 1st April 2019 Gabapentin is re-classified as a Schedule 3 Controlled Drug

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
Controlled Drug Pregabalin
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Formulary
Amber

Pregabalin Capsule 25mg
Pregabalin Capsule 50mg
Pregabalin Capsule 75mg
Pregabalin Capsule 100mg
Pregabalin Capsule 150mg
Pregabalin Capsule 200mg
Pregabalin Capsule 225mg
Pregabalin Capsule 300mg

Pregabalin Oral Solution 100mg/5ml S/F - for patients with swallowing difficulties ONLY
 
The Capsules are flat priced so dose optimise when increasing Daily Doses, e.g. 1x50mg twice a day is cheaper to prescribe than 2x25mg twice a day.

CDAs of the 1st April 2019 Pregabalin is re-classified as a Schedule 3 Controlled Drug

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Lamotrigine
Lamotrigine
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Formulary
Amber

Lamotrigine Tablet 25mg
Lamotrigine Tablet 50mg
Lamotrigine Tablet 100mg
Lamotrigine Tablet 200mg
Lamotrigine Tablet Dispersible 5mg S/F
Lamotrigine Tablet Dispersible 25mg S/F
Lamotrigine Tablet Dispersible 100mg S/F

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Levetiracetam
Levetiracetam
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Formulary
Amber

Levetiracetam Tablet 250mg
Levetiracetam Tablet 500mg
Levetiracetam Tablet 750mg
Levetiracetam Tablet 1g
Levetiracetam Oral Solution 500mcg/5ml S/F

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Phenytoin
Phenytoin
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Formulary
Amber

Phenytoin Sodium Capsule 25mg
Phenytoin Sodium Capsule 50mg
Phenytoin Sodium Capsule 50mg
Phenytoin Sodium Capsule 100mg
Phenytoin Sodium Capsule 300mg
Phenytoin Oral Liquid

Restriction: Initiation and stabilisation by specialist
Maintain patient on specific manufacturer's products.

 
Link  UKMI Q&A: Information on change of phenytoin capsules to tablets and vice versa
   
04.08.01  Expand sub section  Tiagabine to top
Tiagabine (Gabitril®)
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Formulary
Amber

Tiagabine Tablet 5mg
Tiagabine Tablet 10mg
Tiagabine Tablet 15mg

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Topiramate
Topiramate
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Formulary
Amber

Topiramate Tablet 25mg
Topiramate Tablet 50mg
Topiramate Tablet 100mg
Topiramate Tablet 200mg

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
   
04.08.01  Expand sub section  Valproate
Sodium Valproate
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Formulary
Amber

Sodium Valproate Tablet 100mg
Sodium Valproate Tablet 300mg M/R
Sodium Valproate Tablet 500mg M/R
Sodium Valproate Tablet E/C 200mg
Sodium Valproate Tablet E/C 500mg
Sodium Valproate Oral Solution 200mg/5ml S/F

Restriction: Initiation and stabilisation by specialist
Maintain patient on specific manufacturer's products.

Please see the following links to materials to support the new Valproate Pregnancy Prevention Programme:

Patient Card – to be given by pharmacists to all female patients who are dispensed valproate medicines to inform them of the risks
Patient Guide – to be provided to girls (of any age) and women of childbearing potential (or their parent/caregiver/responsible person) taking any medicine containing valproate
Guide for healthcare professionals – for all prescribers, pharmacists, and other healthcare providers involved in the care of women and girls of childbearing potential using valproate medicines
• Risk Acknowledgment form – for the specialist and patient (or their parent/caregiver/responsible person) to sign at initiation and at treatment reviews at least every year. The patient should receive a copy of the form; one copy should be filed in the specialist notes, and one copy sent to the patient’s GP

 
Link  Medicines related to valproate: risk of abnormal pregnancy outcomes
Link  MHRA Guidance : Stronger advice on the use of valproate medicines in women
   
04.08.01  Expand sub section  Vigabatrin
Vigabatrin (Sabril®)
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Formulary
Amber E

Vigabatrin Tablet 500mg
Vigabatrin Powder Sachet 500mg S/F

Supported by ESCA only where agreed from initiating trust (see links below)

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products

 
Link  ESCA: Birmingham and surrounds
Link  ESCA: Children with epilepsy (for DTHFT only)
   
04.08.01  Expand sub section  Zonisamide
Zonisamide
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Formulary
Amber E

Zonisamide 25mg capsules
Zonisamide 50mg capsules
Zonisamide 100mg capsules

Should be initiated by a specialist and suitable for continuation in primary care with ESCA - see link below

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products

 
Link  Birmingham ESCA
   
04.08.01  Expand sub section  Other Drugs to top
Perampanel (Fycompa®)
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Formulary
Red

Perampanel 2mg tablets
Perampanel 4mg tablets
Perampanel 6mg tablets
Perampanel 8mg tablets
Perampanel 10mg tablets
Perampanel 12mg tablets

Restriction: By specialist only
Unnecessary to maintain patient on specific manufacturer's products.

 
Link  NICE CG137: The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care
   
Retigabine
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Formulary
Amber

Retigabine Tablet 50mg
Retigabine Tablet 100mg
Retigabine Tablet 200mg
Retigabine Tablet 300mg
Retigabine Tablet 400mg

Retigabine for the adjunctive treatment of partial onset seizures in epilepsy, see TA232.

Discontinued June 2017See manufacturer's note

 
Link  NICE TA232: Retigabine for the adjunctive treatment of adults with partial onset seizures in epilepsy with and without secondary generalisation
   
Rufinamide (Inovelon®)
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Formulary
Amber

Rufinamide Tablet 100mg
Rufinamide Tablet 200mg
Rufinamide Tablet 400mg
Rufinamide Oral Suspension 40mg/1ml S/F

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products

 
   
04.08.02  Expand sub section  Drugs used in status epilepticus
Clonazepam
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Formulary
Amber

Clonazepam Tablets 500mcg
Clonazepam Tablets 2mg
Oral solution 500mcg/5ml
Oral Solution 2mg/5ml 
 
 

 

 
   
Diazepam Rectal Tubes
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Formulary
Green
Diazepam Solution 2.5mg/1.25ml Rectal Tube
 
   
Controlled Drug Midazolam (Buccolam)
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Formulary
Green
Buccolam Pre-filled Syringe 0.5ml(2.5mg)
Buccolam Pre-filled Syringe 1ml(5mg)
Buccolam Pre-filled Syringe 1.5ml(7.5mg)
Buccolam Pre-filled Syringe 2ml(10mg)

Only Licensed for patients between 3 months and 18 years of age.

No Licensed Preparation for over 18 year olds. Preferred prescribe Buccolam off label


 
   
04.08.03  Expand sub section  Febrile convulsions
04.09  Expand sub section  Drugs used in parkinsonism and related disorders
04.09.01  Expand sub section  Dopaminergic drugs used in Parkinsons disease
Co-careldopa
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Formulary
Amber
Co-Careldopa Tablet 10mg/100mg 25mg/100mg 25mg/250mg
Co-Careldopa Tablet MR tablets 25mg/100mg 50mg/200mg

Prescribe Generically.
 
   
Rasagiline
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Amber
Rasagiline Mesil_Tablet 1mg 
   
Amantadine
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Formulary
Amber

•Capsules
•Syrup- for patients with swallowing difficulties
To be initiated by a specialist and then transferred to primary care

 
   
04.09.01  Expand sub section  Dopamine receptor agonists to top
Apomorphine
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Formulary
Amber E

Apomorphine HCl Injection 10mg/ml 2ml Amp

Supported by ESCA only where agreed from initiating trust 

 
   
Pramipexole
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Formulary
Amber

pramipexole 0.088 mg tablets
pramipexole 0.18 mg tablets
pramipexole0.35 mg tablets
pramipexole 0.7 mg tablets
 

 
   
Pramipexole modified release tablets (Pipexus®)
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Formulary
Amber
Pipexus 0.26 mg prolonged-release tablets
Pipexus 0.52 mg prolonged-release tablets
Pipexus 1.05 mg prolonged-release tablets
Pipexus 1.57 mg prolonged-release tablets
Pipexus 2.10 mg prolonged-release tablets
Pipexus 2.62 mg prolonged-release tablets
Pipexus 3.15 mg prolonged-release tablets

Please prescribe Pramipexole MR as most cost effective brand in primary care Pipexus ®  
   
Ropinirole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Restriction: Initiation and stabilisation by specialist

Ropinirole HCl Tab 250mcg
Ropinirole HCl Tab 500mcg
Ropinirole HCl Tab 1mg
Ropinirole HCl Tab 2mg
Ropinirole HCl Tab 5mg

Ropinirole HCl Tab 2mg M/R 
Ropinirole HCl Tab 3mg M/R  
Ropinirole HCl Tab 4mg M/R
Ropinirole HCl Tab 6mg M/R  
Ropinirole HCl Tab 8mg M/R
 
Ipinnia XL or Repinex XL are the preferred cost-effective MR brands (Applicable in primary care).

 
   
04.09.01  Expand sub section  Levodopa
Co-Beneldopa (Madopar®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Co-Beneldopa Capsule 12.5mg/50mg
Co-Beneldopa Capsule 25mg/100mg
Co-Beneldopa Capsule 25mg/100mg M/R
Co-Beneldopa Capsule 50mg/200mg
Co-Beneldopa Tablet Dispersible 12.5mg/50mg S/F
Co-Beneldopa Tablet Dispersible 25mg/100mg S/F

 
Link  UKMI Q&A: Guidance on converting from MR formulation to dispersible tablets
   
Co-careldopa and entacapone (Stanek®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Please prescribe by brand Stanek® (equivalent to stalevo®) as more cost effective

Stanek 50 mg/12.5 mg/200 mg
Stanek 75 mg/18.75 mg/200mg
Stanek 100 mg/25 mg/200 mg
Stanek 125 mg/31.25 mg/200 mg
Stanek 150 mg/37.5 mg/200 mg
Stanek 175 mg/43.75 mg/200 mg
Stanek 200 mg/50 mg/200 mg


Ingredients are levodopa/carbidopa/entacapone

 
   
04.09.01  Expand sub section  Monoamine-oxidase-B inhibitors
Selegiline Hydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Selegiline HCl Tablet 5mg
Selegiline HCl Tablet 10mg
 
   
04.09.01  Expand sub section  Catachol-O-methyltransferase inhibitors
Entacapone (Comtess®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Entacapone Tablet 200mg
 
   
04.09.02  Expand sub section  Antimuscarinic drugs used in parkinsonism
Procyclidine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
Procyclidine HCl Tablet 5mg 
   
04.09.03  Expand sub section  Drugs used in essential tremor, chorea, tics, and related disorders to top
Riluzole (Rilutek ®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E
The use of Riluzole for the treatment of Motor Neurone Disease

Initiated in secondary care then continued with ESCA from the trust initiated in. 
Link  NICE TA 20: Guidance on the use of Riluzole (Rilutek) for the treatment of Motor Neurone Disease
   
04.10  Expand sub section  Drugs used in substance dependence
04.10.01  Expand sub section  Alcohol dependence
Acamprosate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Restriction: Initiation by substance abuse unit, no prescribing by General Practice

Patients with alcohol dependence should be referred using the GP surgeries clinical systems online referral form.

  • Staffordshire CCG’s – Humankind - Staffordshire treatment and recovery service (STARS) – Link to website


 

 
   
Nalmefene
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Restriction: In line with NICE Guidance only

Restriction: Initiation by substance abuse unit, no prescribing by General Practice

Patients with alcohol dependence should be referred using the GP surgeries clinical systems online referral form.

  • Staffordshire CCG’s – Humankind - Staffordshire treatment and recovery service (STARS) – Link to website
 
Link  NICE TA325: Nalmefene for reducing alcohol consumption in people with alcohol dependence
   
04.10.02  Expand sub section  Nicotine dependence
 note 

Everyone Health, the service provider for smoking cessation service confirms it is now open to all tobacco smokers, living anywhere in Staffordshire, aged 40 years and over. Referrals can still be made by calling the contact centre on 0333 005 0095, or via email: eh.staffs@nhs.net

Link to website - everyonehealth.co.uk

Nicotine Replacement Therapy
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Restriction: As part of a smoking cessation programme or during inpatient stay only.

Commissioned by Staffordshire County Council. GPs should not routinely prescribe; patients should be directed to a local provider of stop smoking services to access support and treatment.

Self Care Self Care Medicine-Available OTC for self-care.

 
Link  My Health and Wellbeing Planner
Link  UKMI Q&A: Smoking and Drug Interactions
   
Varenicline (Champix®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Varenicline Tart Tablet 0.5mg
Varenicline Tart Tablet 1mg

Varenicline Starter Pack (11 x 500mcg Tabs + 14 x 1mg Tabs)

Restriction: As part of a smoking cessation programme only.

 
Link  NICE TA123: Varenicline
   
Bupropion Hydrochloride (Zyban®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Bupropion HCl Tablet 150mg M/R
 
Restriction: As part of a smoking cessation programme only.
 

MHRA/CHM advice: Bupropion (Zyban®): risk of serotonin syndrome with use with other serotonergic drugs (November 2020)

 
   
04.10.03  Expand sub section  Opioid dependence
04.10.03  Expand sub section  Opioid substitution therapy to top
Controlled Drug Buprenorphine (Subutex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Buprenorphine_Tab Subling 400mcg S/F
Buprenorphine_Tab Subling 2mg S/F
Buprenorphine_Tab Subling 8mg S/F
Subutex_Tab Subling 2mg
Subutex_Tab Subling 400mcg
Subutex_Tab Subling 8mg 
 
 

From April 1st 2017 there should be no prescribing of medications within primary care for alcohol or substance misuse. New patients should be referred into the One Recovery specialist service.

One Recovery are working to repatriate patients back into their specialist services but if there any queries related to specific patients it is recommended that these are directed to the service.

Stafford Tel: 01785- 270080

Cannock Tel: 01543-468667


 
 

 
   
Controlled Drug Buprenorphine and Naloxone (Suboxone®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Suboxone_Tab Subling 2mg/0.5mg
Suboxone_Tab Subling 8mg/2mg 
 

From April 1st 2017 there should be no prescribing of medications within primary care for alcohol or substance misuse. New patients should be referred into the One Recovery specialist service.

One Recovery are working to repatriate patients back into their specialist services but if there any queries related to specific patients it is recommended that these are directed to the service.

Stafford Tel: 01785- 270080

Cannock Tel: 01543-468667

 

 
   
Controlled Drug Methadone
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Methadone HCl_Mix 1mg/1ml
 

From April 1st 2017 there should be no prescribing of medications within primary care for alcohol or substance misuse. New patients should be referred into the One Recovery specialist service.

One Recovery are working to repatriate patients back into their specialist services but if there any queries related to specific patients it is recommended that these are directed to the service.

Stafford Tel: 01785- 270080

Cannock Tel: 01543-468667


 

 
   
04.10.03  Expand sub section  Opioid-receptor antagonists
Naltrexone (Nalorex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted

From April 1st 2017 there should be no prescribing of medications within primary care for alcohol or substance misuse. New patients should be referred into the One Recovery specialist service.

One Recovery are working to repatriate patients back into their specialist services but if there any queries related to specific patients it is recommended that these are directed to the service.

Stafford Tel: 01785- 270080

Cannock Tel: 01543-468667

 
Link  NICE TA115: Drug misuse - naltrexone
   
04.11  Expand sub section  Drugs for dementia
Donepezil (Aricept®)
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Formulary
Amber E

Donepezil HCl Tablet 5mg
Donepezil HCl Tablet 10mg
Donepezil HCl_Orodisper Tablet 5mg
Donepezil HCl_Orodisper Tablet 10mg

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Galantamine (Reminyl®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Galantamine_Tablet 8mg
Galantamine_Tablet 12mg

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Galantamine M/R capsules (Galzemic XL capsules® )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Galantamine XL 8mg Capsules
Galamtamine XL 16mg capsules
Galantamine XL 24mg capsules

Please prescribe by brand name GALZEMIC XL as this is most cost effective option.

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
Link  Information from NICE
   
Memantine (Ebixa®)
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Formulary
Amber E

Memantine HCl_Tablet 10mg
Memantine HCl_Tablet 20mg

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
Rivastigmine (Alzest®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Rivastigmine_Cap 1.5mg
Rivastigmine_Cap 3mg
Rivastigmine_Cap 4.5mg
Rivastigmine_Cap 6mg
Rivastigmine_Oral Soln 2mg/1ml
Rivastigmine_Oral Soln 2mg/1ml S/F
Rivastigmine_Skin Patch 4.6mg/24hrs
Rivastigmine_Skin Patch 9.5mg/24hrs
Rivastigmine_Skin Patch 13.3mg/24hrs

Patches should only be used in patients with swallowing difficulties and should be prescribed as Alzest which is more cost effective in primary care.

See link below for ESCA. Please use the ESCA under the title Agreements - South Staffordshire CCG Locality

 
Link  Essential Shared Care Agreements (ESCA’s) - MPFT
   
04.12  Expand sub section  Drugs for sialorrhoea
Botulinum neurotoxin Type A (Xeomin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
CCG
BlueTeq

Restriction: In line with NICE Guidance only

An option for treating chronic sialorrhoea caused by neurological conditions in adults. Specialist use only. 

 
Link  NICE TA605: Xeomin (botulinum neurotoxin type A) for treating chronic sialorrhoea
   
 ....
 Non Formulary Items
Acetazolamide

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Non Formulary
 
actipatch

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Non Formulary

Pulsed electromagnetic stimulator patches

This has recently been made available on the NHS. locally the evidence needs to be reviewed before a decision can be made as to whether this is supported locally.

Currently it is non formulary.

 
Agomelatine  (Valdoxan®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Alfentanyl Sublingual Spray 5 mg in 5mL

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Almotriptan  (Almogran®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Alprazolam

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Non Formulary
 
Alprazolam  (Xanax®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Amisulpride  (Solian®)

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Non Formulary
 
Amitriptyline and perphenazine  (Triptafen®)

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Non Formulary
 
Amitriptyline and perphenazine  (Triptafen-M®)

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Non Formulary
 
Controlled Drug  Amobarbital (amylobarbitone) and secobarbital (quinalbarbitone)  (Tuinal®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Amobarbital (amylobrbitone)  (Sodium Amytal®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Asenapine

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Aspirin  (Caprin®)

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Non Formulary
 
Aspirin  (Nu-Seals® Aspirin)

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Non Formulary
 
Aspirin and codeine  (Co-codaprin®)

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Non Formulary
 
Aspirin and papaveretum  (Aspav®)

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Non Formulary
 
Benperidol  (Anquil®)

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Non Formulary
 
Benzatropine

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Non Formulary
 
Betahistine Dihydrochloride  (Serc®)

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Non Formulary
 
Botulinum Toxin Type A  (Xeomin®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary This is an NHS England Specialised Commissioning Drug for Focal Spasticity in Children
This is a Specialised Drug which would not be routinely commissioned by CCGs for Intravesical use in Spinal Cord Injury. This would go through a South Staffs CCGs Individual Funding Request (IFR)
 
Bromocriptine

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Non Formulary
 
Controlled Drug  Buprenorphine  (Temgesic®)

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Non Formulary
 
Controlled Drug  Buprenorphine 5mcg Patch  (Butrans®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary Butrans non-formulary please prescribe branded generic Butec as more cost effective. Butec is made in the same manufacturing unit as Butrans.
 
Controlled Drug  Butobarbital (butobarbitone)  (Soneryl®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cabergoline  (Cabaser®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Chlorpromazine Hydrochloride  (Largactil®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cinnarizine  (Stugeron®)

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Non Formulary
 
Cinnarizine and Dimenhydrinate  (Arlevert®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Clomipramine  (Anafranil® SR)

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Non Formulary
 
Clomipramine Hydrochloride  (Anafranil®)

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Non Formulary
 
Clonidine Hydrochloride

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Non Formulary
 
Clonidine Hydrochloride  (Catapres®)

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Non Formulary
 
Clonidine Hydrochloride  (Dixarit®)

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Non Formulary
 
Clonidine Hydrochloride  (Dixarit®)

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Non Formulary
 
Clozapine  (Denzapine®)

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Non Formulary
 
Co-Careldopa  (Half Sinemet ®CR)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary prescribe generically
 
Co-Careldopa  (Sinemet Plus®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

prescribe generically

 
Co-Careldopa  (Sinemet®)

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Non Formulary prescribe generically
 
Co-Careldopa  (Sinemet® CR)

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Non Formulary prescribe generically
 
Co-Careldopa and Entacapone  (Stalevo®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary The stalevo® brand is non formulary as stanek® is more cost effective
 
Co-Careldopa Intestinal Gel

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Non Formulary This is a Specialised Drug which would not be routinely commissioned by CCGs for Parkinson's disease. This would go through a South Staffs CCGs Individual Funding Request (IFR)
 
Co-proxamol

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Non Formulary

NHS England Guidance for CCGs4:

  • prescribers in primary care should not initiate co-proxamol for any new patient.
  • prescribers should be supported in deprescribing co-proxamol in all patients and, where appropriate, ensure the availability of relevant services to facilitate this change.

No routine exceptions have been identified.

Alternative analgesics e.g. paracetamol and codeine or co-codamol tablets.

 
Controlled Drug  Dextromoramide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Dipipanone  (Diconal®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Disulfiram  (Antabuse®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Dolasetron Mesilate  (Anzemet®)

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Non Formulary
 
Domperidone  (Motilium®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Dosulepin Hydrochloride  (Prothiaden®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Doxepin  (Sinepin®)

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Non Formulary
 
Eletriptan  (Relpax®)

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Non Formulary
 
Ergotamine Tartrate  ((Cafergot®))

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Non Formulary NON formulary not recommended for prescribing
 
Ergotamine Tartrate  (Migril®)

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Non Formulary Non formulary not recommended to prescribe
 
Ethosuximide  (Emeside®)

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Non Formulary

prescribe generically-note liquid cheaper then capsules

Restriction: Initiation and stabilisation by specialist
Unnecessary to maintain patient on specific manufacturer's products.

 
Controlled Drug  Fentanyl  (Actiq®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Controlled Drug  Fentanyl  (Effentora® buccal tablets)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Controlled Drug  Fentanyl  (Instanyl® nasal spray)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Fentanyl Buccal Film  (Breakyl)

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Non Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Controlled Drug  Fentanyl Nasal Spray  (PecFent®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Controlled Drug  Fentanyl sublingual tablets  (Abstral®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Fluoxetine  (Prozac®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Flupentixol  (Depixol®)

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Non Formulary
 
Flupentixol  (Fluanxol®)

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Non Formulary
 
Fluphenazine Hydrochloride  (Moditen®)

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Non Formulary
 
Flurazepam  (Dalmane®)

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Non Formulary
 
Fluvoxamine Maleate  (Faverin®)

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Non Formulary
 
Fluvoxamine Maleate  (Fluvoxamine®)

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Non Formulary
 
Fosaprepitant  (Ivemend®)

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Non Formulary
 
Fosphenytoin Sodium  (Pro-Epanutin®)

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Non Formulary
 
Galantamine  (Galsya XL)

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Non Formulary This brand is non formulary as more cost effective to prescribe Gatalin XL brand of galatamine modified release
 
Galantamine  (Reminyl® XL)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary This brand is non formulary as more cost effective to prescribe Gatalin XL brand of galatamine modified release
 
Granisetron transdermal patch  (Sancuso®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Haloperidol  (Dozic®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Haloperidol  (Haldol®)

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Non Formulary
 
Haloperidol  (Serenace®)

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Non Formulary
 
Controlled Drug  Hydromorphone  (Palladone®)

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Non Formulary
 
Controlled Drug  Hydromorphone Hydrochloride  (Palladone® SR)

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Non Formulary
 
Imipramine

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Isocarboxazid

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Non Formulary
 
Ketamine oral solution

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Non Formulary
 
Lamotrigine  (Lamictal®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Levomepromazine  (Nozinan®)

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Non Formulary
 
LEVOMEPROMAZINE (METHOTRIMEPRAZINE)

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Non Formulary
 
Lisuride

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Loprazolam

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Non Formulary
 
Lurasidone  (Latuda®)

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Non Formulary
 
Meptazinol  (Meptid®)

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Non Formulary
 
Controlled Drug  Methadone

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Methylphenidate Hydrochloride  (Equasym® XL)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Methylphenidate Hydrochloride  (Ritalin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Methysergide  (Deseril®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Metoclopramide Hydrochloride  (Maxolon®)

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Non Formulary
 
Metoclopramide Hydrochloride  (Maxolon® High Dose)

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Non Formulary
 
Metoclopramide Hydrochloride  (Maxolon® SR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Mirtazapine  (Zispin® SolTab)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary Prescribe generically
 
Modafinil  (Provigil®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

MHRA/CHM advice (updated November 2020): Modafinil (Provigil®): increased risk of congenital malformations if used during pregnancy

 
Controlled Drug  Morphine and cyclizine  (Cyclimorph®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Morphine Sulfate  (MST Continus®tablets)

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Non Formulary

Non formulary as is more cost effective to prescribe as Zomorph capsules

 
Controlled Drug  Morphine Sulfate  (Oramorph®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

Please prescribe generically

 
Controlled Drug  Morphine Sulfate  (Sevredol®tablets)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Naltrexone

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Naltrexone-bupropion  (Mysimba®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

Not supported by NICE

Link  NICE TA494: Naltrexone–bupropion for managing overweight and obesity
 
Naratriptan  (Naramig®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nefopam

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nefopam  (Acupan®)

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Non Formulary
 
Nitrazepam

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Non Formulary
 
Nortriptyline  (Allegron®)

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Non Formulary
 
Olanzapine Embonate  (ZypAdhera®)

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Non Formulary
 
Ondansetron  (Zofran®)

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Non Formulary Do not prescribe this brand, prescribe generically where appropriate as indicated by formulary entry
 
Orphenadrine

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Non Formulary
 
Orphenadrine Hydrochloride  (Biophen®)

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Non Formulary
 
Orphenadrine Hydrochloride  (Disipal®)

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Non Formulary
 
Oxazepam

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Non Formulary
 
Paliperidone

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Non Formulary
 
Palonosetron  (Aloxi®)

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Non Formulary
 
Controlled Drug  Papaveretum

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Non Formulary
 
Controlled Drug  Papaveretum

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Non Formulary
 
Paracetamol  (Panadol OA®)

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Non Formulary
 
Paracetamol  (Perfalgan®)

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Non Formulary
 
Paracetamol and codeine  (Codipir®)

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Non Formulary
 
Paracetamol and codeine  (Kapake®)

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Non Formulary
 
Paracetamol and codeine  (Solpadol®)

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Non Formulary
 
Paracetamol and codeine  (Tylex®)

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Non Formulary
 
Paracetamol and dihydrocodeine  (Co-dydramol®)

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Non Formulary
 
Paracetamol and dihydrocodeine  (Remedeine®)

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Non Formulary
 
Paracetamol and methionine  (Pardote®)

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Non Formulary
 
Paraldehyde

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Non Formulary
 
Paroxetine  (Seroxat®)

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Non Formulary
 
Controlled Drug  Pentazocine

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Non Formulary
 
Pergolide  (Celance®)

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Non Formulary non formulary- NICE states rarely used now due to fibrotic reactions for which there has been a MHRA safety warning
 
Pericyazine  (Neilactil®)

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Non Formulary
 
Perphenazine

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Non Formulary
 
Perphenazine  (Fentazin®)

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Non Formulary
 
Controlled Drug  Pethidine

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Non Formulary
 
Controlled Drug  Pethidine Hydrochloride and promethazine  (Pamergan® P100)

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Non Formulary
 
Phenelzine  (Nardil®)

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Non Formulary
 
Controlled Drug  Phenobarbital

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Non Formulary
 
Phenytoin  (Epanutin®)

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Non Formulary
 
Phenytoin Sodium  (Epanutin® Ready Mixed Parenteral)

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Non Formulary
 
Pimozide  (Orap®)

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Non Formulary
 
Pipotiazine Palmitate  (Piportil® Depot)

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Non Formulary
 
Piracetam  (Nootropil®)

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Non Formulary
 
Primidone

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Non Formulary
 
Prochlorperazine

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Non Formulary
 
Prochlorperazine  (Buccastem® (Bucal preparation))

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Non Formulary
 
Prochlorperazine  (Stemetil®)

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Non Formulary
 
Procyclidine Hydrochloride  (Arpicolin®)

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Non Formulary
 
Procyclidine Hydrochloride  (Kemadrin®)

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Non Formulary
 
Promazine Hydrochloride  (Promazine®)

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Non Formulary
 
Promethazine Hydrochloride  (Phenergan)

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Non Formulary
 
Promethazine teoclate  (Avomine®)

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Non Formulary
 
Promethazine Teoclate  (Avomine®)

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Non Formulary
 
Rasagiline  (Azilect®)

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Non Formulary
 
Reboxetine  (Edronex®)

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Non Formulary
 
Rimonabant  (Acomplia®)

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Non Formulary
 
Rotigotine

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Non Formulary
 
Safinamide

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Non Formulary
 
Controlled Drug  Secobarbital (quinalbarbitone)  (Seconal Sodium® )

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Non Formulary
 
Selegiline Hydrochloride  (Eldepryl®)

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Non Formulary
 
Selegiline Hydrochloride  (Zelapar®)

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Non Formulary
 
Sertindole  (Serdolect®)

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Non Formulary
 
Sertraline  (Lustral®)

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Non Formulary
 
Sibutramine Hydrochloride  (Reductil®)

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Non Formulary
 
Sodium Valproate  (Epilim® Intravenous)

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Non Formulary
 
Sulpiride  (Dolmatil®)

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Non Formulary
 
Sulpiride  (Sulpor®)

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Non Formulary
 
Sumatriptan  (Imigran®)

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Non Formulary
 
Sumatriptan  (Imigran® Radis)

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Non Formulary
 
Controlled Drug  Tapentadol  (Palexia®)

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Non Formulary
 
Controlled Drug  Targinact (Oxycodone/Naloxone)  (Targinact®)

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Non Formulary

NHS England Guidance for CCGs4:

    • prescribers in primary care should not initiate oxycodone and naloxone combination product for any new patient.
    • prescribers should be supported in deprescribing oxycodone and naloxone combination product in all patients and, where appropriate, ensure the availability of relevant services to facilitate this change.if, in exceptional circumstances, there is a clinical need for oxycodone and naloxone combination product to be prescribed in primary care, this should be undertaken in a cooperation arrangement with a multi-disciplinary team and/or other healthcare professional.No routine exceptions have been identified. 

 

 
Tetrabenazine  (Xenazine® 25)

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Non Formulary
 
Tolcapone  (Tasmar®)

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Non Formulary
 
Tramadol Hydrochloride  (Dromadol®SR)

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Non Formulary
 
Tramadol Hydrochloride  (Larapam® SR)

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Non Formulary
 
Tramadol Hydrochloride  (Zamadol®)

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Non Formulary
 
Tramadol Hydrochloride  (Zamadol® SR)

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Non Formulary
 
Tramadol Hydrochloride  (Zydol®)

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Non Formulary
 
Tramadol Hydrochloride and paracetamol  (Tramacet®)

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Non Formulary

NHS England Guidance for CCGs:

  • prescribers in primary care should not initiate paracetamol and tramadol combination product for any new patient.
  • prescribers should be supported in deprescribing paracetamol and tramadol combination product in all patients and, where appropriate, ensure the availability of relevant services to facilitate this change.

 

No routine exceptions have been identified.

 
Tramadol MR

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Non Formulary
 
Tramadol oral drops

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Non Formulary
 
Tranylcypromine

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Non Formulary
 
Trifluoperazine

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Non Formulary
 
Trifluoperazine

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Non Formulary
 
Trifluoperazine  (Stelazine®)

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Non Formulary
 
Trihexyphenidyl

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Non Formulary
 
Trihexyphenidyl Hydrochloride  (Broflex®)

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Non Formulary
 
Trimipramine  (Surmontil®)

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Non Formulary
 
Tropisetron  (Navoban®)

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Non Formulary
 
Tryptophan

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Non Formulary
 
Trytophan  (Optimax®)

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Non Formulary
 
Venlafaxine  (Efexor® XL)

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Non Formulary
 
Venlafaxine  (Foraven XL®)

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Non Formulary
 
Venlafaxine  (Valdoxan®)

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Non Formulary
 
Venlafaxine  (Venaxx XL®)

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Non Formulary
 
Venlafaxine  (Venlalic® XL)

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Non Formulary
 
Venlafaxine  (Winfex®)

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Non Formulary
 
Zaleplon  (Sonata®)

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Non Formulary

Zaleplon (Sonata) - DISCONTINUED (Mims June 2015)

 
Ziprasidone  (Zeldox®)

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Non Formulary
 
Zolpidem

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Non Formulary
 
Zolpidem Tartrate  (Stilnoct®)

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Non Formulary
 
Zopiclone  (Zimovane®)

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Non Formulary
 
Zotepine  (Zoleptil®)

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Non Formulary
 
Zuclopenthixol  (Clopixol®)

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Non Formulary
 
Zuclopenthixol Acetate  (Clopixol Acuphase®)

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Non Formulary
 
Zuclopenthixol Decanoate  (Clopixol® Conc.)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Drugs which require special consideration. These are drugs for Consultant Prescribing ONLY. They should not be prescribed in Primary Care.  

Amber

Drugs that should be initiated by a Specialist but are suitable for continuation in Primary Care. For some drugs there may be a Ricad in place to aid the transition to primary care.  

Amber E

Drugs that should be initiated by a Specialist but are suitable for continuation in Primary Care but also require and ESCA (Shared Care Agreement)   

Green

Suitable first-line drugs for implementation in Primary Care  

On Formulary

South Staffs Formulary Choice  

netFormulary