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South Staffordshire Joint Formulary
Cannock Chase Clinical Commissioning Group
East Staffordshire Clinical Commissioning Group
South East Staffordshire and Seisdon Peninsula Clinical Commissioning Group
Stafford and Surrounds Clinical Commissioning Group
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 Formulary Chapter 4: Central nervous system - Full Chapter
04.09  Expand sub section  Drugs used in parkinsonism and related disorders
04.09.01  Expand sub section  Dopaminergic drugs used in Parkinsons disease
Co-careldopa
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Formulary
Amber
Co-Careldopa Tablet 10mg/100mg 25mg/100mg 25mg/250mg
Co-Careldopa Tablet MR tablets 25mg/100mg 50mg/200mg

Prescribe Generically.
 
   
Rasagiline
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Formulary
Amber
Rasagiline Mesil_Tablet 1mg 
   
Amantadine
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Formulary
Amber

•Capsules
•Syrup- for patients with swallowing difficulties
To be initiated by a specialist and then transferred to primary care

 
   
04.09.01  Expand sub section  Dopamine receptor agonists
Apomorphine
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Formulary
Amber E

Apomorphine HCl Injection 10mg/ml 2ml Amp

Supported by ESCA only where agreed from initiating trust 

 
   
Pramipexole
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Formulary
Amber

pramipexole 0.088 mg tablets
pramipexole 0.18 mg tablets
pramipexole0.35 mg tablets
pramipexole 0.7 mg tablets
 

 
   
Pramipexole modified release tablets (Pipexus®)
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Formulary
Amber
Pipexus 0.26 mg prolonged-release tablets
Pipexus 0.52 mg prolonged-release tablets
Pipexus 1.05 mg prolonged-release tablets
Pipexus 1.57 mg prolonged-release tablets
Pipexus 2.10 mg prolonged-release tablets
Pipexus 2.62 mg prolonged-release tablets
Pipexus 3.15 mg prolonged-release tablets

Please prescribe Pramipexole MR as most cost effective brand in primary care Pipexus ®  
   
Ropinirole
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Formulary
Amber

Restriction: Initiation and stabilisation by specialist

Ropinirole HCl Tab 250mcg
Ropinirole HCl Tab 500mcg
Ropinirole HCl Tab 1mg
Ropinirole HCl Tab 2mg
Ropinirole HCl Tab 5mg

Ropinirole HCl Tab 2mg M/R 
Ropinirole HCl Tab 3mg M/R  
Ropinirole HCl Tab 4mg M/R
Ropinirole HCl Tab 6mg M/R  
Ropinirole HCl Tab 8mg M/R
 
Ipinnia XL or Repinex XL are the preferred cost-effective MR brands (Applicable in primary care).

 
   
04.09.01  Expand sub section  Levodopa
Co-Beneldopa (Madopar®)
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Formulary
Amber

Co-Beneldopa Capsule 12.5mg/50mg
Co-Beneldopa Capsule 25mg/100mg
Co-Beneldopa Capsule 25mg/100mg M/R
Co-Beneldopa Capsule 50mg/200mg
Co-Beneldopa Tablet Dispersible 12.5mg/50mg S/F
Co-Beneldopa Tablet Dispersible 25mg/100mg S/F

 
Link  UKMI Q&A: Guidance on converting from MR formulation to dispersible tablets
   
Co-careldopa and entacapone (Stanek®)
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Formulary
Amber

Please prescribe by brand Stanek® (equivalent to stalevo®) as more cost effective

Stanek 50 mg/12.5 mg/200 mg
Stanek 75 mg/18.75 mg/200mg
Stanek 100 mg/25 mg/200 mg
Stanek 125 mg/31.25 mg/200 mg
Stanek 150 mg/37.5 mg/200 mg
Stanek 175 mg/43.75 mg/200 mg
Stanek 200 mg/50 mg/200 mg


Ingredients are levodopa/carbidopa/entacapone

 
   
04.09.01  Expand sub section  Monoamine-oxidase-B inhibitors to top
Selegiline Hydrochloride
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Formulary
Amber
Selegiline HCl Tablet 5mg
Selegiline HCl Tablet 10mg
 
   
04.09.01  Expand sub section  Catachol-O-methyltransferase inhibitors
Entacapone (Comtess®)
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Formulary
Amber
Entacapone Tablet 200mg
 
   
04.09.02  Expand sub section  Antimuscarinic drugs used in parkinsonism
Procyclidine
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Formulary
Green
Procyclidine HCl Tablet 5mg 
   
04.09.03  Expand sub section  Drugs used in essential tremor, chorea, tics, and related disorders
Riluzole (Rilutek ®)
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Formulary
Amber E
The use of Riluzole for the treatment of Motor Neurone Disease

Initiated in secondary care then continued with ESCA from the trust initiated in. 
Link  NICE TA 20: Guidance on the use of Riluzole (Rilutek) for the treatment of Motor Neurone Disease
   
 ....
 Non Formulary Items
Benzatropine

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Non Formulary
 
Botulinum Toxin Type A  (Xeomin®)

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Non Formulary This is an NHS England Specialised Commissioning Drug for Focal Spasticity in Children
This is a Specialised Drug which would not be routinely commissioned by CCGs for Intravesical use in Spinal Cord Injury. This would go through a South Staffs CCGs Individual Funding Request (IFR)
 
Bromocriptine

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Non Formulary
 
Cabergoline  (Cabaser®)

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Non Formulary
 
Co-Careldopa  (Half Sinemet ®CR)

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Non Formulary prescribe generically
 
Co-Careldopa  (Sinemet Plus®)

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Non Formulary

prescribe generically

 
Co-Careldopa  (Sinemet®)

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Non Formulary prescribe generically
 
Co-Careldopa  (Sinemet® CR)

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Non Formulary prescribe generically
 
Co-Careldopa and Entacapone  (Stalevo®)

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Non Formulary The stalevo® brand is non formulary as stanek® is more cost effective
 
Co-Careldopa Intestinal Gel

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Non Formulary This is a Specialised Drug which would not be routinely commissioned by CCGs for Parkinson's disease. This would go through a South Staffs CCGs Individual Funding Request (IFR)
 
Lisuride

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Non Formulary
 
Orphenadrine

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Non Formulary
 
Orphenadrine Hydrochloride  (Biophen®)

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Non Formulary
 
Orphenadrine Hydrochloride  (Disipal®)

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Non Formulary
 
Pergolide  (Celance®)

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Non Formulary non formulary- NICE states rarely used now due to fibrotic reactions for which there has been a MHRA safety warning
 
Piracetam  (Nootropil®)

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Non Formulary
 
Primidone

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Non Formulary
 
Procyclidine Hydrochloride  (Arpicolin®)

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Non Formulary
 
Procyclidine Hydrochloride  (Kemadrin®)

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Non Formulary
 
Rasagiline  (Azilect®)

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Non Formulary
 
Rotigotine

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Non Formulary
 
Safinamide

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Non Formulary
 
Selegiline Hydrochloride  (Eldepryl®)

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Non Formulary
 
Selegiline Hydrochloride  (Zelapar®)

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Non Formulary
 
Tetrabenazine  (Xenazine® 25)

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Non Formulary
 
Tolcapone  (Tasmar®)

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Non Formulary
 
Trihexyphenidyl

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Non Formulary
 
Trihexyphenidyl Hydrochloride  (Broflex®)

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Drugs which require special consideration. These are drugs for Consultant Prescribing ONLY. They should not be prescribed in Primary Care.  

Amber

Drugs that should be initiated by a Specialist but are suitable for continuation in Primary Care. For some drugs there may be a Ricad in place to aid the transition to primary care.  

Amber E

Drugs that should be initiated by a Specialist but are suitable for continuation in Primary Care but also require and ESCA (Shared Care Agreement)   

Green

Suitable first-line drugs for implementation in Primary Care  

On Formulary

South Staffs Formulary Choice  

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